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rheumatology differential ana antibodies antibody antineutrophil antinuclear aortitis classification comparison dermatology diseases druginduced endocarditis erythematosus glomerulonephritis pericarditis progressive rapidly rpgn
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... nephritis, NPSLE ... Positive in 60-80% of cases ... #lupus #Systemic
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
lupus erythematosus ... Anti-dsDNA (in 70% of cases ... in drug-induced SLE ... seen in 30—70% of cases ... Antineutrophil #antibodies #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... inflammation Others: • Lupus ... lupus erythematosus ... , and SLE) • Urinalysis
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Algorithm Vesicles ... • Bullous systemic ... lupus erythematous ... Vesiculobullous #SkinRash ... #Algorithm #causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... #differential #diagnosis ... #algorithm #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... months to years) Systemic ... nephritis, NPSLE ... Positive in 60-80% of cases
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... (SLE), Sarcoidosis ... (SPA) • Other Causes ... common bacterial causes ... Mycobacterial Causes
Causes of Pericarditis - Differential Diagnosis Algorithm Viral: • Coxsackie • Echovirus • Adenovirus • Epstein-Barr virus
Causes of Pericarditis ... arthritis • Systemic ... lupus erythematosus ... #Algorithm #Causes ... #Cardiology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... diseases, such as SLE ... tract, and often causes ... - interstitial keratitis
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Autoimmune (SLE ... positive in 90% of IE cases ... Septic Emboli Cause ... valvular disease • Vasculitis ... #management #cardiology
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