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diagnosis ana antinuclear systemic comparison patterns antinxp2 antinxp2dm cerebritis classification cns connectivetissuediseases ctild dermatology diseases druginduced ild lungdisease neurology pulmonary
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Syndrome (SS), Polymyositis ... /Dermatomyositis ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... their Disease Associations ... Polymyositis / Dermatomyositis ... #table #rheumatology ... #antibodies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... is clinically suspected ... overlap syndromes ... #erythematosus ... #table #ANA
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
DM/PM : dermatomyositis ... PSS: Sjogren syndrome ... : systemic lupus ... #Comparison #Table ... #Associations
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... /Dermatomyositis ... : Lupus (SLE), Systemic ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... • Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... , dermatomyositis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
SLE) Clinical ... Demyelinating Syndrome ... Cerebrovascular Disease ... the formation of autoantibodies ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... months) and of autoantibodies ... Erythematosus ( ... : Chronic disease ... #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
such as systemic lupus ... erythematosus, ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... #diagnosis #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... • Antibodies targeting ... had more severe disease ... #diagnosis #management ... #rheumatology #
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