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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Involvement in Systemic Lupus ... Lupusreference #Renal #diseases ... #SLE #Systemic ... #Lupus #Erythematosus ... #venn #nephrology
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Gravis, Graves' Disease ... • Ex: Systemic Lupus ... Syndrome, Contact Dermatitis
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Erythematosus (SLE ... Cerebrovascular Disease ... Erythematosus #SLE ... #CNS #neurology
Demyelinating Diseases - Differential Diagnosis
 • Inflammatory: MS, ADEM, NMO, Paraneoplastic, Sjogren's, Polyarteritis nodosa, SLE
 •
Demyelinating Diseases ... Polyarteritis nodosa, SLE ... Demyelinating #Diseases ... Diagnosis #causes #neurology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
and less common diseases ... Vogt-Koyanagi-Harada (VKH) disease ... syndrome • Systemic lupus ... polychondritis • Behcet disease ... BEE #Syndromes #neurology
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)
SLE patient develops
Lupus Nephritis ... approach to kidney disease ... with systemic lupus ... Non-LN Kidney Disease ... #nephrology #biopsy
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
Syphilis, Lyme disease ... Vasculitis, Sjogren's, Lupus ... Charcot-Marie-Tooth, Fabry's disease ... diagnosis #causes #neurology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... during hemolytic disease ... , and systemic lupus ... - Contact dermatitis
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
lymphoproliferative disease ... nodules, may also see ... • Metastatic disease ... demyelinating diseases ... causes #radiology #neurology
A quick infographic on various pearls about atopic dermatitis, a disease with an increasing burden on
, a disease with ... inflammatory skin disease ... This disease imposes ... #dermatology #skinrash ... Allergy. 2018;73