23 results
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Gravis, Graves' Disease ... • Ex: Systemic Lupus ... #Allergic #Reactions
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... during hemolytic disease ... , and systemic lupus ... Pathophysiology #Allergy
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... ): - Allergic ... Rhinitis - Allergic ... Dermatitis - ... #Causes #hematology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... lgE causes mast-cell ... reaction, Haemolytic disease ... Examples: Contact dermatitis ... #allergy #table
Eczematous Skin Rash - Differential Diagnosis Algorithm
Eczematous - Pruritic/Scaly/Erythematous lesions. Usually poorly demarcated
 • Atopic Dermatitis
- Differential Diagnosis ... anyone - Allergic ... #Eczematous #SkinRash ... #dermatology #Differential ... #causes
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... - Differential Diagnosis ... • Systemic Lupus ... • Acne • Allergy ... #Hematology #Oncology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... S - Systemic Lupus ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
- Differential Diagnosis ... released during an allergic ... Colitis and Crohn’s Disease ... #Differential #Diagnosis ... #causes #hematology
A quick infographic on various pearls about atopic dermatitis, a disease with an increasing burden on
medications #treatment #diagnosis ... #causes #atopy ... #skinrash References ... Allergy. 2018;73 ... J Allergy Clin Immunol
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Cerebrovascular Disease ... autoantibodies that will cause ... #rheumatology # ... cerebritis #diagnosis