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antibodies classification management anca antineutrophil antinuclear autoantibodies comparison cryoglobulinemia cryoglobulins differential druginduced erythematosus systemic types vasculitides
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... c-ANCA - Vasculitis ... #diseases #diagnosis ... #table #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... connective tissue disease ... 90% • Anti-GBM disease ... #rheumatology # ... diseases
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... : - ANA > ... Evolution: Chronic disease ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... Evolution: Chronic disease ... #table #rheumatology ... #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... atherosclerotic disease ... most important diseases ... , and SLE) • Urinalysis ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • Autoimmune diseases ... cytoplasmic antibody ... (e.g. systemic lupus ... classification #rheumatology
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