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diagnosis differential rheumatology oncology hematology manifestations skin syndrome cryoglobulins dermpath erythematosus lesions monoclonal myelodysplastic nonpalpable palpable paraproteinemias pathology purpura semiology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
: CTD: SLE, RA related ... Urticarial/LCV) - Cryoglobulinemic ... Erythema elevatum ... : • Behcet Disease ... #dermatology #rheumatology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... (10%) : SLE +++ ... hemopathies (4%) • Cryoglobulinemia ... #dermatology #semiology ... lesions #diagnosis #clinical
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
appearing during the disease ... Neutrophilic dermatosis ... dermatomyositis, SLE ... leukocytoclastic vasculitis ... #oncology #clinical
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Autoimmune diseases ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
aphthous ulcers, cutaneous ... such as systemic lupus ... strong sign of cutaneous ... , and SLE) • Urinalysis ... #rheumatology #classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Pigmented Purpuric Dermatosis ... /HSP • Cryoglobulinemia ... Associated - SLE ... reactions • Erythema ... #nonpalpable #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Classification: ... • Acute cutaneous ... lymphoproliferative syndrome Clinical
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... • Neutrophilic dermatosis ... gangrenosum • Cutaneous ... leak syndrome • Erythema ... to cold IgG • Lupus
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Most common extra cutaneous ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
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