12 results
Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
#SLE #Systemic ... #Lupus #Erythematosus ... #venn #nephrology ... classification #types ... #rheumatology
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Gravis, Graves' Disease ... • Ex: Systemic Lupus ... Erythematosus, ... Syndrome, Contact Dermatitis ... #Diagnosis #Definitions
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... Cerebrovascular Disease ... the formation of autoantibodies ... #SLE #CNS #neurology ... #rheumatology #
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Lupusreference #SLE ... #Erythematosus ... #Diagnosis #autoantibodies ... #differential #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... • Type-I Interferonopathies ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... with auto-immune diseases ... #Antinuclear #autoantibodies ... #erythematosus ... #diagnosis #rheumatology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
during hemolytic disease ... , and systemic lupus ... erythematosus ... - Contact dermatitis ... #Reactions #Table
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
months) and of autoantibodies ... Erythematosus ( ... Evolution: Chronic disease ... #table #rheumatology ... #diagnosis #management
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... : - 10% SLE or ... (e.g. systemic lupus ... erythematosus ( ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
such as systemic lupus ... erythematosus, ... , drug reactions ... vasculitis, and SLE ... #rheumatology #