13 results
Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Lupus Erythematosus ... Lupusreference #Renal #diseases ... #SLE #Systemic ... #venn #nephrology ... classification #types #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... /systemic sclerosis ... #Lupus #Erythematosus ... diagnosis #rheumatology ... #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management ... : Chronic disease ... #lupus #Systemic ... #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... Cerebrovascular Disease ... #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... - Local and systemic ... during hemolytic disease ... lupus erythematosus ... - Contact dermatitis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... • Systemic lupus ... [SLE], AOSD) • ... • Drug-induced hypersensitivity ... Syndrome #Diagnosis #Management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... Chronic B-cell activation ... #Systemic #Lupus ... Erythematosus #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... Usual therapeutic management ... : Chronic disease ... #table #rheumatology ... #diagnosis #management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
to complement activation ... reaction, Haemolytic disease ... glomerulonephritis, Systemic ... lupus erythematosus ... Examples: Contact dermatitis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... : - 10% SLE or ... vasculitis • Hypersensitivity ... lupus erythematosus ... classification #rheumatology