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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal #diseases #SLE ... #Systemic #Lupus ... Erythematosus #venn #nephrology ... classification #types ... #rheumatology
Lupus Nephritis Classification Algorithm

#Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Classification #Algorithm #diagnosis ... #differential #types ... #rheumatology # ... nephrology #renal
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... Labs/Diagnosis: ... (e.g. systemic lupus ... erythematosus (SLE ... #rheumatology #
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
neuropathy • Type ... min/1.73 m2 at diagnosis ... • Dialysis at diagnosis ... Vasculitis #Management #Rheumatology ... #Nephrology
Approach to a Positive (+) Rheumatoid Factor (RF)
(+) RF does not always = RA
Rheumatic disorders:
 •
arthritis • SLE ... connective tissue (types ... III) • Mixed cryoglobulinemia ... Rheumatoid #Factor #RF #rheumatology ... #differential #diagnosis
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Mnemonic C - Cryoglobulinemia ... 1 (50%-80%), type ... S - Systemic Lupus ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Erythematosus #SLE ... #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
IgA nephropathy, lupus ... nephritis, cryoglobulinemia ... autoAb against type ... #Differential #Diagnosis ... #Nephrology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Pigmented Purpuric Dermatosis ... vasculitis/HSP • Cryoglobulinemia ... Associated - SLE ... #hematology #rheumatology
Cutaneous Lupus Erythematosus
 • Acute Cutaneous Lupus (ACLE)
 • Neutrophilic Dermatoses 
 • Vascular Lesions
 •
Cutaneous Lupus ... Acute Cutaneous Lupus ... (SCLE) • Intermittent ... Erythematosus #diagnosis ... #types #venn #rheumatology