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algorithm chronic leukemia cd4 cvid diffuse disorders gap globulin hemeonc hypogammaglobulinemia icl idiopathic immunodeficiency lad lymphadenopathy lymphocytopenia lymphopenia lymphoproliferative mds
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphoma SLL ... ’s lymphoma or acute ... lymphoma • Hairy ... #workup #oncology ... #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Lymphoma - Reed-Sternberg ... Cells on Biopsy ... Lymphoma #Diffuse ... #Causes #Hematology ... #Oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Hodgkin Lymphoma ... lymphomas (NHL) ... - T Cell ~10% ... - B-Cell ~90% ... pathophysiology #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's Lymphoma ... of cases) Classification ... Lymphoma Treatment ... #lymphoma #diagnosis ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... Transformation to large cell ... lymphoma (Richter ... #hematology #hemeonc ... #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
lymphoma • B cell ... lymphoma • Large ... B cell lymphoma ... • MALT Lymphoma ... Diagnosis #Management
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Persistent CD4 T-cell ... deficiencies • CD4 T-cell ... mL or 20% total lymphocyte ... Unc119) • Heme (lymphoma ... #hematology #Differential
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... hepatitis • Lymphoma ... Granulomatous lymphocytic ... DDX - Other causes ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Most common cytopenia ... blood count with differential ... #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Amyloidosis • Lymphoma ... myeloma • Plasma cell ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... #diagnosis #hematology
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