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diagnosis algorithm apml chronic cll cvid differentiation disorders gap globulin hodgkins hypogammaglobulinemia immunodeficiency immunology leukemia lymphocytic lymphomas lymphoproliferative mds myelodysplasia
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... site in lymphatic system ... with lymphatic system ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
(NSHL) - (most common ... Workup: • Full ... Treatment • Early ... #hematology #oncology ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Epidemiology: • Most common ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Causes: - Idiopathic ... (malignancy), lymphoma ... Treatment: - Systemic ... #diagnosis #dermatology ... #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hepatitis • Lymphoma ... • Nodules • Lymphoid ... hemolytic anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Most common cytopenia ... blood count with differential ... #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... Comment on type ... #diagnosis #hematology
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