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diagnosis hematology anemia blood hemolytic product classification coagulation dermatologic dic disseminated extravascular gpa granulomatosis nonpalpable palpable polyangiitis taco thromboticthrombocytopenicpurpura trali
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... thrombocytopenic purpura ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Transfusion Reaction ... maculopapular rash ... Causes purpura & ... #diagnosis #management ... #hematology #reactions
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... IVIG infusion Intravascular ... prosthetic valve • Transfusion ... reactions ex. ... classification #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
maculopapular rash ... Purpura (PTP): ... Causes purpura & ... #diagnosis #management ... #hematology #reactions
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... fever • Drug reactions ... Diagnosis #hematology ... #nonpalpable #dermatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Reactions TRALI ... without other cause ... #Reactions #hematology ... #diagnosis #comparison ... #table
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Maculopapular rash ... reticularis Differential ... #rash #diagnosis ... #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Thrombocytopenic Purpura ... decrease in most cases ... reflection of intravascular ... WBC count and differential ... Diagnosis #Workup #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Petechiae • Purpura ... Treat primary cause ... #treatment #management ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... disease, drug reactions ... , mucositis • Rash ... tract, and often causes ... #Diagnosis #Rheumatology
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