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diagnosis management rheumatology hematology syndrome systemic erythematosus gammopathy hemeonc hemepath hemophagocytic hepatology hepatorenal hlh hrs igg4 lupus lymphohistiocytosis macrophage mastocytosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Presentation: • Rapid development ... Fever is the main clinical ... nervous system (CNS) dysfunction ... Histopathologic criteria
Guide to systemic mastocytosis Criteria for diagnosis: at least 1 major and 1 minor or 3 minor
mastocytosis Criteria ... minor or 3 minor criteria ... without organ dysfunction ... hemepath #pathology #algorithm ... #diagnosis #clinical
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... • Essential Criteria ... : Clinical/radiologic ... complement • Classification ... 2019 ACR/EULAR Criteria
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
sympathetic + ADH activation ... Diagnosis (Clinical ... Criteria): • ↑ ... Classification: ... be substituted as
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Skin Disease Classification ... lymphoproliferative syndrome Clinical ... mild cognitive dysfunction ... Chronic B-cell activation
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... (often termed MAS-HLH ... Clinical Presentation ... Diagnostic Criteria ... of 8 HLH-2004 criteria
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
does not meet criteria ... misclassified as ... Clinical Clues: ... guide subtype classification ... Complement pathway activation
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