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management antibiotics infant lp pediatrics stepbystep stratification acute apml cancer capillary clarksons comparison criteria dermatology dermatosis differentiation disease ebm gout
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... an infant with fever ... CRP < 20 mg/L #Diagnosis ... Management #Pediatrics #Peds ... #Febrile #Infant
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Attempt if high risk ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... Imaging: CXR- pulmonary ... #management #hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
: 33% • Treatment ... , and CXR with pulmonary ... edema) • Fever ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
Diagnostic Criteria ... (Acute Febrile ... Fever, temperature ... Excellent response to treatment ... #Hematology #Dermatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... organ damage • Treatment ... : - If febrile ... #TLS #diagnosis ... #management #hematology
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... empiric antibiotic treatment ... 92.0% and 46.9% #Diagnosis ... Management #Pediatrics #Peds ... Stratification #Fever
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... acute or subacute febrile ... following: • Fever ... • Bicytopenia Treatment ... #hematology
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
vascular filling +++ (risk ... of pulmonary edema ... Prevention of at-risk ... #diagnosis #management ... #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
effusion, INC risk ... PE, Pulmonary amyloidosis ... Malignancy Risk ... Adenocarcinoma Treatment ... #Rheumatology #
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
inflammatory response Risk ... sex • Metabolic syndrome ... 12-24 Hours • Fever ... drug failure • Risk ... #rheumatology
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