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hemophagocytic lymphohistiocytosis oncology activation algorithm anemia antiphospholipid aplastic cerebritis cns erythematosus hypercoagulable mas mds myelodysplastic neurology sapho sle systemic workup
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... SJIA], systemic lupus ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with excessive macrophage ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Summary myelo ( ... old, ~10,000 new cases ... #Management #treatment ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
activation of macrophages ... Drugs, Unknown cause ... Treatment: • ... #management #treatment ... #summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... (for secondary APS ... CNS #neurology #rheumatology ... #management #treatment
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... Rule out other causes ... #Rheumatology # ... diagnosis #management ... #Dermatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
(APLS) Testing ... maternal chromosomal causes ... excluded Testing: • Lupus ... Workup #Algorithm #diagnosis ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - Antithyroid medications ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
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