14 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Unexplained hypokalemia ... #Syndrome #diagnosis ... #nephrology #management ... #Hypokalemia
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... Diagnosis Algorithm ... , Gitelman's syndrome ... diagnosis #algorithm ... #causes #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... , Gitelman syndrom ... Diagnosis #Algorithm ... #low #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... Diagnosis Algorithm ... , Gitelman's syndrome ... #Hypokalemia # ... #Algorithm #nephrology
Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Hypertension - BP > 140/90 (>130/80 for DM)
Hypertensive urgency
Diagnosis Algorithm ... • AKI/CKD Mineralocorticoid ... Hyperthyroidism • Hypercalcemia ... HTN #Secondary #Nephrology ... Diagnosis #Algorithm
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... evaluating hypokalemia ... , Gitelman syndrome ... #diagnosis #Algorithm ... potassium #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Pre-Renal: • Hypovolemia ... Distributive Shock, HRS, Hypercalcemia ... Abdominal Compartment Syndrome ... #Diagnosis #nephrology ... #causes #algorithm
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
, Gitelman syndrome ... Hypomagnesemia • Hypertension ... the indicated causes ... #nephrology #differential ... #diagnosis
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Muscle pain - Weakness ... • LDH ↑ • Hyperkalemia ... injured muscles - HYPOTENSION ... Dialysis for severe hyperkalemia ... #nephrology