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management hematology signs differential leukemia oncology algorithm immunodeficiency infectiousdiseases neurology rheumatology syndrome vasculitis workup 1 acute biliary bulimianervosa cancer cdi
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... (Chronic Lymphocytic ... CLL Symptoms: • ... Transformation: • Complication ... of Chronic Lymphocytic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... Diagnosis: • ... cells can indicate disease ... #Chronic #Lymphocytic
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... minimal tumor burden Diagnosis ... thrombocytopenia Complications ... chemotherapy for low-risk disease ... #Chronic #Lymphocytic
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
and duration of symptoms ... angioedema Other symptoms ... infiltration (lymphocytes ... , Chronic spontaneous ... urticaria, Chronic
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
CRP Neuronal cell ... Sydenham's Chorea Lymphocytes ... RheumaticFever #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Hashitoxicosis ‘Leakage’ symptoms of active Hashimoto’s disease - Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in
the thyroid by lymphocytes ... ‘Leakage’ symptoms ... due to thyroid cell ... Endocrinology #Diagnosis ... #Pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... : • T lymphocyte ... PBC Signs and Symptoms ... but elevated as disease ... , IgG4 related disease
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... noninfectious complications ... Autoimmunity • Chronic ... Granulomatous lymphocytic ... Malignancies • Chronic
Gastroesophageal Reflux Disease (GERD) - Summary GERD: Diagnosis • Heartburn (substernal burning sensation) and acid regurgitation • Chest pain Extraesophageal
Gastroesophageal Reflux Disease ... Summary GERD: Diagnosis ... throat clearing, chronic ... GERD - Complications ... #Gastroenterology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
severe clinical complications ... Malnutrition due to chronic ... disease/malabsorptive ... overload) Other Symptoms ... #Pathophysiology
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