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differential causes algorithm binders binding comparison diuresis diuretics druginduced excretion hypokalemia management pathophysiology renal treatment
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... Increased EC shift of K ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... patients sensitive to high ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Medications 2. ... #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... • Recent IV potassium ... Medications 2. ... #high #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Etiology: • Medications ... Elimination (see Table ... STOP offending medications ... #nephrology #K
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Loop Diuretics; High-Ceiling ... Hyponatremia • Hypercalcemia ... syndrome • Lithium-induced ... #Pharmacology # ... Medications #Table
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
urine Na/Cl < 0.7, high ... Tubulopathy: urine K/ ... correcting serum potassium ... Other medications ... #algorithm #nephrology
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