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diabetes summary agonists inhibitors apml diagnosis differentiation dosing dpp4 hematology management oncology receptor sglt2
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
- Pharmacology ... outcomes in high risk ... effect) • May ↑ risk ... #Summary #DM2 # ... diabetes #endocrinology
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
carrying only a low risk ... GI tract) and injection ... #Pharmacology #Dosing ... #Diabetes #DM2 ... #Endocrinology
SGLT2 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
Jardiance) - Best risk ... mortality in high risk ... Canagliflozin ↑ risk ... #Summary #DM2 # ... diabetes #endocrinology
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... normally inactivates GLP ... associated with t risk ... #Summary #DM2 # ... diabetes #endocrinology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Attempt if high risk ... day vs. 2.5 mg/m2 ... Imaging: CXR- pulmonary ... Differential Diagnosis: Infection
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