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AKI in Cirrhosis - Hepatorenal Syndrome Management Algorithm

DOI: 10.1136/bmj.m2687

#AKI #Cirrhosis #Hepatorenal #Syndrome #HRS #Management #Algorithm #nephrology
AKI in Cirrhosis ... - Hepatorenal Syndrome ... #Hepatorenal #Syndrome ... #HRS #Management ... #Algorithm #nephrology
 End Stage Liver Disease (Cirrhosis) - Complications 
 • Ascites
 • Esophageal Varices
 • Hepatic
Liver Disease (Cirrhosis ... Hepatopulmonary Syndrome ... (HPS) • Hepatorenal ... Syndrom (HRS) ... Complications #diagnosis #management
Pharmacological Treatment of Hepatorenal Syndrome (HRS)

Midodrine - Alpha agonist incr blood pressure incr renal perfusion pressure
Syndrome (HRS) ... pressure incr renal ... #HepatoRenal #Syndrome ... #Nephrology #Management ... #Pharmacology #Medications
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
Hepatorenal Syndrome ... in 3 months • Cirrhosis ... haematuria, Normal renal ... disease - Cirrhosis ... #Hepatorenal #Syndrome
Hepatorenal Syndrome Diagnosis
 • ↑ in serum Cr of ≥ 0.3mg/dL above baseline
Hepatorenal Syndrome ... (e.g. advanced cirrhosis ... significantly improve renal ... #Syndrome #diagnosis ... #HRS #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Distributive Shock, HRS ... Abdominal Compartment Syndrome ... , Medications Intra-Renal ... Protein) • AIN: Medication ... Differential #Diagnosis #nephrology
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
Albumin for Management ... of Cirrhosis ... antibiotics • Hepatorenal ... syndrome - 1g/ ... #Management #Cirrhosis
Hepatorenal Syndrome - Diagnosis and Management Summary
Who gets HRS?
 • Decompensated cirrhosis
 • Typically with existing
Hepatorenal Syndrome ... Diagnosis and Management ... Decompensated cirrhosis ... a precipitant: Medications ... #Syndrome #HRS
Hepatorenal Syndrome Treatment
Volume expansion: 
 • Albumin (typical dose = 1g/kg on day 1 +/- day
Hepatorenal Syndrome ... EricsMedicalLectures/ #Hepatorenal ... #Syndrome #Treatment ... #management #HRS ... #nephrology
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
a.k.a. cardiorenal syndrome ... failure (a.k.a. hepatorenal ... syndrome) Intrarenal ... vasculitis - TTP/HUS ... tract infection • Medications