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differential hematology management oncology algorithm thrombocytopenia ai anemia blood classification dermatology endocrinology insufficiency intravascular mds myelodysplastic neurology product purpura reactions
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm ACTH-Dependent (Secondary): • Pituitary Dysfunction • Hypothalamic Dysfunction ACTH-Independent (Primary):
Causes of Adrenal ... Polyglandular Autoimmune Syndrome ... • Infectious: ... TB, Disseminated ... Fungal, HIV/AIDS
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • DIC ... Vasculitis • Infection ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome
Infectious Causes of Adrenal Insufficiency Anatomical distribution of vessels to the adrenal makes the gland prone to
Infectious Causes ... infection or disseminated ... Waterhouse-Friderichsen syndrome ... canimorsus • Virus: HIV ... #Causes #Adrenal
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): - Disseminated ... intravascular coagulation (DIC ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... Drugs (Beta lactam antibiotics
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... old, ~10,000 new cases ... risk-stratification • Risks: infection ... Myelodysplastic #Syndrome
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... etc) - Viral: HIV ... infiltration: malignancy, infection ... Microangiopathy: DIC ... antiphospholipid syndrome
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... • HCV, HBV Not ... #hematology #rheumatology
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Causes of Antibiotic ... NMS, serotonin syndrome ... Immunocompromise Treatment ... • Secondary to Treatment ... : IV catheter (CLABSI
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Acute Retroviral Syndrome ... Acute Retroviral Syndrome ... mononucleosis/flu type of syndrome ... Acute Retroviral Syndrome ... Acute #Retroviral #Syndrome
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