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Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... Coagulation (DIC ... INR < 2.3 - APTT ... #Disseminated # ... treatment #management #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Scoring System for Disseminated ... (DIC) Platelet ... aggregation PT, aPTT ... #Disseminated # ... Scoring #diagnosis #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... Disseminated intravascular ... coagulation (DIC ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
the PT and the aPTT ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... #differential #hematology ... #coagulation
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... conditions such as disseminated ... intravascular coagulation ... count, D-dimer, egg ... hemolytic #anemia #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): - Disseminated ... intravascular coagulation ... (DIC) - HELLP ... (usually IgG) (e.g ... differential #diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... Warfarin • Acute DIC ... liver failure, disseminated ... disease • Acute DIC ... Differential #Diagnosis #Hematology
Torsades de Pointes
• "Twisting of the pointes" 
• QRS axis swings from positive to negative direction
Originates from single focus ... quridine) Class IC ... TorsadesDePointes #Diagnosis #Cardiology ... #ECG #EKG
Constrictive Pericarditis on Echocardiogram
A 55-year-old female marathon runner presents to clinic w/ 6-months of worsening breathlessness
had gained 15 kg ... We did a transthoracic ... Echocardiogram #a4c #pocus ... #clinical #cardiology