23 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... life-threatening • Treatment ... Evolution: Chronic disease ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... Diagnosis via genetic ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Treatment: • ... #SLE #Summary #diagnosis ... #rheumatology # ... management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... permeability Diagnosis ... CNS #neurology #rheumatology ... #cerebritis #diagnosis ... #management #treatment
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... Evolution: Chronic disease ... comparison #table #rheumatology ... #diagnosis #management
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
Treatment depends ... brain injury By Association ... Anesthesiology #Anesthesia ... #Checklist #Diagnosis ... #Management #Workup
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... • Systemic lupus ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
and Management ... screening for disease ... Avoid meds that ... #Management #treatment ... #hematology
Intraoperative Tachycardia - Guidelines for Crises in Anaesthesia
Tachycardia in theatre is often due to inadequate depth
remember to tailor treatment ... (→ 3-8) By Association ... Anesthesiology #Anesthesia ... Intraoperative #Checklist #Diagnosis ... #Management #Workup