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diagnosis dermatology differential lupus management dermatomyositis sle symptoms systemic vasculitis acute ana antimda5 antimda5dm antinuclear antinxp2 antinxp2dm autoantibodies autoimmune behcet
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... SLE-SSc-AlM overlap syndromes ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Demyelinating syndromes ... pain (20%) Renal disease ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
Criteria for Sweet Syndrome ... onset of tender erythematous ... Association with ... inflammatory disease ... Criteria #Diagnosis #Hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
with edema • Erythematous ... violaceous macules and erythematous ... severity of the disease ... frequently described Association ... Dermatomyositis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... Asia • HLA-B51 association ... tests in Behcet syndrome ... diagnosis #management #signs ... #symptoms #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... cells can indicate disease ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Systemic Lupus Erythematosus ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemia - Skin: erythematous ... • Cogan Syndrome ... systemic lupus erythematosus ... purpura: strong sign ... differential #diagnosis #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Myeloproliferative Disease ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... ischemia • Skin: Erythematous ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
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