78 results
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Hyperferritinemia Pearl: Diseases ... Still's disease ... Systemic histoplasmosis ... Differential #Diagnosis #Hematology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... solid cancers • Systemic ... #AdultOnset #Stills ... #management #treatment ... #rheumatology
Seronegative Inflammatory Arthritis - Differential Diagnosis
 • Seronegative Rheumatoid Arthritis 
 • Infectious Arthritis: Viral, Bacterial,
Rheumatic Disease ... Sclerosis, Sjogren's Disease ... , Sarcoidosis, Still's ... Disease, Inflammatory ... Differential #Diagnosis #rheumatology
Still's Disease: Characteristic rash seen in the adult form of this disease. 
Photo credit, Josh Fierer,
Still's Disease: ... adult form of this disease ... Clinical #Photo #Dermatology ... #SkinRash #Adult
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Initial screening test ... • MCTD (SLE/systemic ... Summary #diagnosis #rheumatology ... #management
Pyoderma Gangrenosum: Autoimmune disorder resulting in a vasculitis which causes slowly progressive 
ulceration of the skin.
a number of systemic ... diseases, it is ... inflammatory bowel disease ... Clinical #Photo #Dermatology ... #SkinRash #Pyoderma
Urticaria (hives): Skin reaction that occurs in response to cold, food allergies, meds, environmental exposures, stings,
infections
environmental exposures, stings ... associated with systemic ... Clinical #Photo #Dermatology ... #SkinRash #Urticaria
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... episode (30%) Systemic ... #Disease #AOSD ... #management #treatment
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
• Increased Destruction ... ASA) • Renal Disease ... Vascular System ... TeIangiectasia Vascular System ... Algorithm #Causes #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Adult-onset Still ... diseaseSystemic ... Liver function tests ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology