13 results
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Indications and Pharmacology ... Inhibits plasminogen activation ... reduces complement activation ... diarrhea & abdominal pain ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... can mimic common infections ... agent are the main ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
B for initial management ... severe fungal infections ... ) - Main adverse ... effects = Hematologic ... #Pharmacology #Antibiotics
IDSA Recommendations for Preventing and Treating Chagas Disease (American Trypanosomiasis) in HIV-AIDS
Preventing Clinical Disease
Indication:  Individuals
ART may prevent reactivation ... Prevention #Treatment #management ... #opportunistic ... #infections #HIVAIDS ... #pharmacology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... • Fever is the main ... SLE], AOSD) • Infection ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Diagnosis and Management ... skin necrosis (at injection ... complex → plt activation ... Management: • ... #Treatment #Hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
lesions + Rheumatic pain ... thickening • Osteitis: pain ... causes such as infectious ... #diagnosis #management ... #Dermatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
effusions, weight gain ... Differential Diagnosis: Infection ... APML #diagnosis #management ... #hematology #oncology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
: Fever, flank pain ... Infection - Infection ... likely to cause infections ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
: Fever, flank pain ... • Infection - ... Infection occurs ... Transfusions #diagnosis #management ... #hematology #reactions