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rheumatology signs differential management algorithm lupus msk pathophysiology sle systemic causes clinical erythematosus hepatology abdominal alkaline alp ana ankylosingspondylitis antibodies
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune disease ... elbows/wrists and knees ... interstitial lung disease ... #rheumatology #diagnosis ... #signs #symptoms
Lyme Disease: Early and Late Clinical manifestations Stage 1. Localized • EM appears 7-14 days at the
Lyme Disease: Early ... Large joints (knees ... WuidQ #Lyme #Disease ... #diagnosis #signs ... #symptoms
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Most common symptoms ... - Bone symptoms ... - PSC - Other ... #Differential #Diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Erythematosus - Diagnosis ... 60-70% - Anti-SSA ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs #symptoms
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
ANA ≠ Autoimmune Disease ... context of other symptoms ... Sjogren's Syndrome (SS ... or scleroderma (SSc ... #rheumatology #diagnosis
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
immune-mediated disease ... end-stage liver disease ... asymptomatic at diagnosis ... Care focuses on symptom ... #Cholangitis #diagnosis
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
- Differential Diagnosis ... Inflammatory Bowel Disease ... should have other symptoms ... Amy Chung, MD, MSc ... #Differential #Diagnosis
Hansen's Disease (Leprosy) • Transmission - not completely understood, ?nasal droplets • Symptoms appear ~5 years
Hansen's Disease ... nasal droplets • Symptoms ... do not contract disease ... Infiltration of dermis & SC ... #Leprosy #diagnosis
Popliteal (Baker’s) Cyst: Pathogenesis and clinical findings • Idiopathic • Meniscal Lesions • Osteoarthritis • Rheumatoid
intra-articular knee ... underlying joint disease ... #Popliteal #BakersCyst ... pathophysiology #signs #symptoms ... #diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
meningitis), MCC CNS symptoms ... (SVC/IVC occlusion ... artery aneurysms Diagnosis ... ) Differential Diagnosis ... management #signs #symptoms
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