20 results
Immune Checkpoint Inhibitors

PD-1 inhibitors
 - Nivolumab
 - Pembrolizumab
CTLA-4 inhibitors
 - Ipilimumab
 - Tremelimumab
PD-L1 inhibitors
 - Atezolizumab
Immune Checkpoint ... Atezolizumab - Durvalumab ... #Immune #Checkpoint
Checkpoint inhibitors and indications
Anti CTLA-4 antibody:
 • Ipilimumab: Malignant melanoma, Renal cell cancer
Anti-PD-1 antibody:
 • Nivolumab:
Checkpoint inhibitors ... Breast cancer • Durvalumab ... cell cancer #Checkpoint
The Cell Cycle
The cell cycle is the series of tightly regulated steps that controls cell growth
through the G1/S checkpoint ... /S, S/G2, G2/M checkpoints ... the cell cycle checkpoints ... proliferation #TF #E2F #checkpoint
Undifferentiated shock - Algorithm for the Evaluation of Hypotension. This process for the evaluation of hypotension
halting at evaluable checkpoints
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
anti-metabolite - Immune Checkpoint
Immune-related adverse events (irAE) of  immune checkpoint inhibitors (ICI) 

- By Antoine Briantais 
Dr. Benjamin
irAE) of immune checkpoint
Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs)

What are the side effects?
 -
by stopping the checkpoint
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Erdheim-Chester), Immune Checkpoint
Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer - Progression-free Survival in the Intention-to-Treat Population.
Durvalumab after ... Honc #PACIFIC #Durvalumab
Pulmonary complications of targeted therapy
-Immune checkpoint inhibitors (e.g. pembrolizumab)
-Pneumonitis is uncommon (~5% of patients) but can
therapy -Immune checkpoint