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diagnosis syndrome neurology treatment differential workup classification hemophagocytic hlh lupus lymphohistiocytosis nephrology signs symptoms abscess acidosis activation algorithm anemia anesthesia
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... Insufficient blood ... (e.g. renal failure ... #rheumatology # ... levels #lupus #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
) Clinical Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Iron Deficiency (Eg ... Blood Loss, Occult ... Other • e.g ... HgbE, HgbC, etc. ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
plateletcount), peripheral blood ... function test, ANA (e.g ... ., SLE), anti-phospholipid ... or if a primary hematologic ... #Workup #hematology
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Transfusions: Cellular blood ... HLA-selected products (e.g ... Irradiation #RBC #Blood ... #Indications #Hematology ... #BloodBank #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Phagocytosis of blood ... Autoimmune diseases: SLE ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... erythematosus [SLE ... • Infection (eg ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... inflammatory disease (e.g ... Chemistry profile (e.g ... ANA and RF (if clinical ... diagnosis #testing #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... tissue disorder (e.g ... classification #rheumatology
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