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diagnosis differential treatment rheumatology neurology signs algorithm cardiology criticalcare dermatology sle anemia barre checklist classification druginduced emergency erythematosus guillain hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... (usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Other brainstem syndromes ... (e.g. oculomotor ... Hypothalamic or thalamic syndromes ... AQP4-lgG disease; e.g ... erythematosus, Sjögren syndrome
Proposed Algorithm for Diagnosing Sarcoidosis Highly suggestive Clinicoradiological Findings → Clinical diagnosis (without biopsy) e.g. Löfgren's syndrome Suggestive
without biopsy) e.g ... Löfgren's syndrome ... and/or cytology (e.g ... of alternative causes ... Algorithm #diagnosis #Workup
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Infected thrombosis, (e.g ... Lemierre's syndrome ... Malignancy: - Hematologic ... Inflammatory Diseases (e.g ... . autoimmune): Lupus
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Neuroleptic malignant syndrome ... (e.g. haloperidol ... • Serotonin syndrome ... Anticholinergic syndrome ... Sympathomimetic syndrome
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... Lumbar Puncture, EEG ... cerebritis #diagnosis #management
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
BEE Syndromes - ... skull neoplasms (e.g ... recessive—Usher syndrome ... MS • Other • Syndromes ... aura #BEE #Syndromes
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... underlying disease (eg ... • Infection (eg ... hypersensitivity syndromes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... • Immunologic Workup ... constitutional symptoms ... • Immunologic Workup
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... hyperviscosity syndrome ... rasburicase Tumor Lysis Syndrome ... unless worrisome EKG ... #Tumor #Lysis #Syndrome
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