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differential coagulation algorithm management abnormal pt disorders thrombocytopenia treatment 4tscore activation anemia arterial atlas bleeding blood bloodcell bruising comparison cryofibrinogenemia
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
K Antagonists, Heparin ... to identify the cause ... of Prolonged APTT ... #prolonged #diagnosis ... #hematology #evaluation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
e.g. heparin ... Reduced liver synthesis ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT • Prolonged ... #Differential #Diagnosis ... #Algorithm #Causes ... #Hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... deficiency • Reduced ... #Prolonged #Causes ... #hematology #coagulation
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Causes of Splenomegaly ... - Differential Diagnosis ... Hepatic, Portal, ... #Differential #Diagnosis ... #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... • Acute DIC - Septic ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
4-T Score for the Likelihood of Heparin Induced Thrombocytopenia - Thrombocytopenia - Compare the highest platelet count
Likelihood of Heparin ... Induced Thrombocytopenia ... Other potential cause ... #Likelihood #Diagnosis ... #Hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... DILI) - Stepwise Diagnosis ... for alternative causes ... liver disease, Hepatic ... #Algorithm #hepatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
is prolonged, but ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... Management #treatment #hematology
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