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differential management causes comparison nomenclature platelet rheumatology syndrome activation algorithm anemia basics bleeding blood bloodcell bruising coagulation defects deficiencies deficiency
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
- Differential Diagnosis ... Algorithm Thrombocytopenia ... Sequestration Disordered ... Rare • Drugs (e.g ... Algorithm #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... function test, ANA (e.g ... or if a primary hematologic ... #Differential #Diagnosis ... Causes #Workup #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Unstable hemoglobin disorders ... #differential #diagnosis ... #hematology #microscopy ... #atlas #nomenclature
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malignancy, Autoimmune disorders ... (e.g. ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... lymphoproliferative disorders ... #differential #diagnosis ... #hematology #anemia
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... MYH9-Related Disorder ... Defects #comparison #table ... #differential #diagnosis ... #hematology
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
amyloidosis, or related disorder ... chemotherapy, etc ... possible malignancy (e.g ... Electrophoresis #SPEP #Hematology ... #Diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
leukopenia, anemia, and thrombocytopenia ... Histopathologic criteria ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
chronic inflammatory disorder ... Autoinflammatory disorder ... antiinflammatory properties e.g ... Tetracyclines etc ... #Dermatology
Primary Dermatological Lesions Primary lesions are physical changes in the skin considered to be caused directly by
altered colour e.g ... a generalized disorder ... nettle sting #Diagnosis ... #Dermatology #Skin ... #Nomenclature #Atlas
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