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ekg electrocardiogram classes classification classi pathophysiology torsadesdepointes agents antidepressants approach avr blockers changes channel clinical ddi differential digitalis digoxin drugdrug
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
Class I Antiarrhythmics ... and their Key Pharmacologic ... results in prolonged QT ... #Class1 #Antiarrhythmics ... Agents #Cardiology
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Antiarrhythmics ... Classification Class ... potential • Prolongs QT ... EricsMedicalLectures/ #Antiarrhythmics ... #cardiology #pharmacology
Antiarrhythmics - Sodium Channel Blockers Subclasses, Mechanisms, Indications, Side Effects la - Quinidine, Procainamide lb - Lidocaine, Mexiletine Ic -
Antiarrhythmics ... Channel #Blockers #ClassI ... #Na #cardiology ... #pharmacology # ... table #comparison
Torsades de Pointes •Precipitated by drugs that prolong the QT interval •Class IA antidysrhythmics (procainamide, quinidine)
that prolong the QT ... interval •Class ... quinidine) •Class ... TorsadesDePointes #Diagnosis ... #Cardiology #ECG
TCA Overdose on EKG • Sinus tachycardia • QRS prolongation • QT prolongation • Rightward deviation
TCA Overdose on EKG ... prolongation • QT ... #ECG #electrocardiogram ... #cardiology #diagnosis ... #clinical #criteria
Torsades de Pointes • "Twisting of the pointes" • QRS axis swings from positive to negative direction
that prolong the QT ... interval Class ... quridine) Class ... TorsadesDePointes #Diagnosis ... #Cardiology #ECG
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Antiarrhythmics ... Duration) - ↑ QT ... inotropy) ACCP Cardiology ... Vaughan #Williams #Pharmacology ... pathophysiology #cardiology
Approach to ECGs Check - Age, gender, name - 25mm/s; 10mm/mV - 1mm = 40ms; 0.1 mV Rate
ICD/pacer - QTc ... DANGER - Short QT ... : ↑ca - Long QT ... #EKG #diagnosis ... electrocardiogram #cardiology
Electrocardiographic Features of Digoxin Toxicity • Virtually any arrhythmia is possible. None specific for digoxin toxicity
digoxin toxicity • Classic ... Shortening of QT ... Electrocardiogram #ekg ... #ecg #toxicology ... #cardiology #diagnosis
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Antiarrhythmics ... Pharmacology Summary ... Duration) - ↑ QT ... inotropy) ACCP Cardiology ... #Pharmacology #
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