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algorithm causes management abnormal arthritis coagulation disorders laboratory pain prolonged syndrome activation anemia approach arteritis ascites atlas autoimmune bloodcell conditions
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Diagnosis Algorithm ... /uL Initial Workup ... iron studies, PT ... /aPTT Differential ... #hematology #workup
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... inhibitory drugs (e.g ... specific inhibitor (e.g ... hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
to one factor e.g ... inhibitory drugs e.g ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... #hematology #pathophysiology ... #hematology #laboratory
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
• Provoked (e.g ... - No other workup ... screening, CBC, aPTT ... #hematology #diagnosis ... #algorithm #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... selected cases: INR/PT ... , aPTT(liver disease ... function test, ANA (e.g ... #Workup #hematology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
alterations (e.g ... #Pain #MSK #rheumatology ... #approach #workup ... #differential # ... diagnosis #arthritis
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... mild cases) • PT ... hemophilia type (e.g ... Management #treatment #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Diagnosis Algorithm ... Iron Deficiency (Eg ... Other • e.g ... HgbE, HgbC, etc. ... #Causes #Hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... 1,500 cells/µL Workup ... signs or symptoms (eg ... Disorders #Algorithm #Differential ... #diagnosis #hematology
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