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rheumatology management differential lupus syndrome activation algorithm antibodies arteritis associations autoantibodies causes cerebritis chronic classification cns coagulation conditions cryoglobulinemia cryoglobulins
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
retinal exudates) - SLE ... Neurologic system ... disease, Vasculitis (e.g ... #differential #diagnosis ... #rheumatology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Autoimmune disorders (e.g ... RA, SLE), Post-partum ... #comparison #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- Vasculitis, e.g ... - Vasculitis, e.g ... Microscopic polyangiitis ... Associations #diseases #diagnosis ... #table #rheumatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Rheumatoid Arthritis ... • SLE • Polymyalgia ... Pulmonary Disease Neurologic ... • Drug Abuse (e.g
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Lumbar Puncture, EEG ... Treatment: ... #CNS #neurology ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... life-threatening • Treatment ... #comparison #table ... #rheumatology # ... diagnosis #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
polarized light microscopy ... inflammatory disease (e.g ... Chemistry profile (e.g ... (to support a diagnosis ... laboratory #workup #diagnosis
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... vision changes, etc ... Treatment of GCA
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... Labs/Diagnosis: ... vasculitis - GPA, EGPA, microscopic ... tissue disorder (e.g ... erythematosus (SLE
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... erythematosus [SLE ... • Infection (eg ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
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