19 results
Venous Thromboembolism Treatment Algorithm
Branch points: 
Active bleeding?  Active malignancy? Provoked?

- Dr. Joseph Shatzel
@Clotmaster

#Management #VTE #DVT
Thromboembolism Treatment ... points: Active bleeding ... Active malignancy ... Thromboembolism #Treatment ... #Hematology #Anticoagulation
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
Bleeding risk calculators ... validated for VTE treatment ... of withholding anticoagulation ... Calculators #Anticoagulation ... #Factors #Hematology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
for VTE in Malignancy ... #DOAC #VTE #Malignancy ... Cancer #Algorithm #Anticoagulation ... #Management #Hematology ... #Oncology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Patient risk stratification ... algorithm for the treatment ... #DOAC #VTE #Malignancy ... #Management #Hematology ... #Oncology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
Over-anticoagulation ... lead to severe bleeding ... #pharmacology #treatment ... #medications #table ... decisionaid #cardiology #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
hemophilia type (e.g ... Classify severity Treatment ... by a hemophilia treatment ... risk ... #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
older 50-70 • Malignant ... Hepatosplenomegaly, cytopenias(bleeding ... Lymphomas • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... DOACs thereby leading ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
chemotherapy, etc ... attributed to possible malignancy ... (e.g., associated ... pain, abnormal bleeding ... Electrophoresis #SPEP #Hematology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... mg/dL or > 25 % rise ... Simultaneous clotting and bleeding ... stenting - Consider anticoagulation ... Hypercalcemia of malignancy