31 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
allergy, drug reaction ... glucocorticoid treatment ... signs or symptoms (eg ... , skin or esophageal ... Differential #diagnosis #hematology
Symptoms Distinguishing Groups of Cutaneous Drug Reactions
IgE-mediated reactions:
 • Onset minutes to hours into treatment course
to hours into treatment ... Raised off of the skin ... Onset days into treatment ... Blistering and/or skin ... #dermatology #clinical
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Treatment
Stop offending agents:
 • List as allergies
Drug Reaction with ... DRESS) Syndrome Treatment ... cyclosporine, IVIG etc ... • Skin: topical ... #Management #dermatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
- Transfusion Reactions ... Risk factors: Critical ... without other cause ... #hematology #diagnosis ... #comparison #table
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
characterized by extensive skin ... Edema in 70% of cases ... Skin involvement ... disease: symptomatic treatment ... DRESS #Syndrome #dermatology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
39 C this is a clinical ... Treatment depends ... maintained fever CAUSES ... transfusion • Allergic reaction ... Diagnosis #Management #Workup
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
toxic aetiology: Skin ... to HDS, drugs, OTC ... non-essential drug/HDS treatments ... for alternative causes ... Diagnosis #Algorithm #hepatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
haptoglobin, ↑LDH, etc ... Causes purpura & ... TRALI): Leading cause ... infections with skin ... diagnosis #management #hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Rule out other causes ... and lower jaw Treatment ... Tetracyclines etc ... diagnosis #management #Dermatology
Cardiac Tamponade - Guidelines for Crises in Anaesthesia
Caused by an accumulation of blood, pus, effusion fluid
in Anaesthesia Caused ... , e.g. central line ... thoracotomy is a better treatment ... drape overlying skin ... Diagnosis #Management #Workup