16 results
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
• Inflammatory arthritis ... Noninflammatory arthritis ... with rheumatoid arthritis ... oxalate Infectious Arthritis ... #diagnosis #arthritis
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... HUGE treatment ... and first-line treatment ... Comparison #Diagnosis #Table ... #Hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
to Joint Pain - Arthritis ... • Psoriatic arthritis ... • Reactive arthritis ... • Lyme arthritis ... #Arthritis #
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... ) Giant cell arteritis ... versus Temporal Arteritis ... classic temporal arteritis ... #GiantCell #arteritis
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Fever, Arthralgia/arthritis ... fraction < 20% Differential ... Complications: MAS ... diagnosis #management #treatment ... #rheumatology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
glucocorticoid treatment ... may be indicated ... signs or symptoms (eg ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
early evening • Arthritis ... Arthralgias or arthritis ... or extremities during ... mL Gf consider MAS ... Treatment - Mild
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Activation Syndrome (MAS ... juvenile idiopathic arthritis ... juvenile idiopathic arthritis ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Liver Disease, MDS ... Chemotherapy (e.g ... Liver disease, Etc ... RBC #Morphology #differential ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, inflammatory arthritis ... permanent alopecia Differential ... vasculitis, rheumatoid arthritis ... lung syndrome Arthritis ... Symptoms limited to: Arthritis