13 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Causes of Extravascular ... Cold AIHA • PCH ... immune-complex hemolytic anemia ... Prosthetic heart valves ... #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
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Systemic Lupus Erythematosus ... - Hemolytic anemia ... (aPL) 30-45% Differential ... autoantibodies #signs ... #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Antiribosomal P, APLA, PAC ... lymphopenia, low PLT • Anemia ... #Diagnosis #Rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... hallmark for the disease ... If the value is ... WBC count and differential ... Diagnosis #Workup #Hematology
Gout (Gouty Arthritis) - MSK Radiology
Imaging Findings:
 • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Gouty Arthritis) - MSK ... mass and NO prior signs ... Differential diagnosis ... diffuse chondral disease ... #rheumatology
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... an underlying cause ... that a one-off value ... Better call hematology ... Algorithm #workup #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... ischemia - Skin: erythematous ... systemic lupus erythematosus ... purpura: strong sign ... #diagnosis #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... noninflammatory Signs ... weeks) Can Be Caused ... #Diagnosis #MSK ... #rheumatology #
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... or sed rate): Value ... very remarkable w/differential ... systemic complaints- anemia ... them, but urgent rheumatology