21 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... Other: NAFLD, Autoimmune ... , 1° PSC, Cystic ... #Injury #Differential ... Acute #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Ischemia • Autoimmune ... • Drugs • AIH ... • Cholestatic disease
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
common in SLE, autoimmune ... Dermatomyositis Anti-LKM (liver ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... • Alloimmune ... • PCH ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... • Autoimmune: ... Autoimmune hepatitis ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... ) or metabolic liver ... #AIH
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... from subclinical disease ... to acute liver ... hepatocellular pattern of liver ... been reported (eg AIH-PBC
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... markers such as ELF ... force impulse; ELF ... 4, fibrosis-4; HCC ... Referral #Management #Hepatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
EBV infection, Autoimmune ... diseasesClinical ... the spleen or liver ... Pylori) - Autoimmune ... #hematology