19 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... , Cold AIHA, Transfusion ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Intravascular Hemolysis - Differential ... • Cold AIHA ... AIHA • PCH ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Drugs • AIH ... • Cholestatic disease ... Bile Ducts • PSC
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... markers such as ELF ... force impulse; ELF ... 4, fibrosis-4; HCC ... Referral #Management #Hepatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
women • 15% of AIHA ... Viral Infection Clinical ... younger pts) Differential ... Hemoglobinuria (PCH ... hemolytic #anemia #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Extrinsic Causes: • Liver ... disease • Hypersplenism ... • AIHA: warm, ... cold, drug induced ... classification #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... in those with CLD ... disease, liver ... Alcohol-Associated Hepatitis (AAH ... Failure #Cirrhosis #Hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... weeks • Typical clinical ... #Disease #Pregnancy ... #hepatology #obstetrics ... hepatitis #comparison #differential
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... ) or metabolic liver ... Possible drug-induced liver ... #AIH
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... to acute liver ... hepatocellular pattern of liver ... been reported (eg AIH-PBC ... Diagnosis #Management #Hepatology