42 results
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Corpuscular Volume (MCV ... ) - Differential ... B12 - Anti-IF Antibodies ... • Rule out B12 and ... Algorithm #Causes #Hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
; common in SLE, ... biliary cirrhosis (PBC ... Endomyseal antibody (EMA ... diagnosis #table #rheumatology ... #antibodies
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
pylori test (GI symptoms ... (e.g., SLE), anti-phospholipid ... antibodies, Quantitative ... anemia (vegan, ... Causes #Workup #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential ... Chronic Bleed - Any ... Reticulocytes, MCV ... Disease • Marrow ... Algorithm #Causes #Hematology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... #Antinuclear #Antibodies ... #ANA #patterns ... #rheumatology #diagnosis ... #differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Hemolytic anemia ... Auto-Antibodies ... : - ANA 95-100% ... autoantibodies #signs #symptoms ... #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... context of other symptoms ... #rheumatology #diagnosis ... #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Sensitive Antibodies ... [PCH] 3. ... of anemia include ... younger pts) Differential ... #hematology #diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... • HCV, HBV Not ... #Diagnosis #hematology ... #rheumatology #