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diagnosis causes hemolysis hemolytic agglutinin classification cold elevation erythematosus extravascular hepatology intravascular lactate lactic lfts liverenzymes lupus management rheumatology sle
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
• Alloimmune ... • PCH ... immune-complex hemolytic anemia ... Prosthetic heart valves ... #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Anemia (AIHA) Treatment ... esp if severe disease ... , Splenectomy, MMF ... #Anemia #AIHA # ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Diagnosis Algorithm ... • Ischemia • Autoimmune ... • Drugs • AIH ... • Cholestatic disease ... Bile Ducts • PSC
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Viral infection, autoimmune ... CLL (older) • Autoimmune ... pts) Differential ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Non-autoimmune ... deficiencies • Autoimmune ... : • AIHA 10% • ... lymphopenia, low PLT • Anemia
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential ... to bolus these values ... presentations and disease ... before beginning treatment ... 30mmHg) - Severe anemia
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