10 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Injury • AST/ALT elevation ... • R value = (ALT ... #Cholestatic #Transaminitis ... #diagnosis #differential ... #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... ALP ≥ 2x ULN R Value ... FunctionTest #LFTs #Elevation ... #Transaminitis ... #diagnosis #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Algorithm for Transaminitis ... Elevated #Abnormal #Transaminitis ... Algorithm #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... #Differential # ... Diagnosis #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... Bilirubin - +/- elevation ... Enzyme Elevation ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Bilirubin - +/- elevation ... Enzyme Elevation ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
to 10-20-fold elevation ... to 10-20-fold elevation ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... markers such as ELF ... force impulse; ELF ... 4, fibrosis-4; HCC ... Referral #Management #Hepatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Causes of Lactate Elevation ... Lactic Acidosis - Differential ... www.ncbi.nlm.nih.gov/pmc ... to bolus these values ... #Differential #