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diagnosis algorithm hepatology causes anemia workup classification injury transaminitis abnormal management mcv atlas bleeding bruising disorders elevation enzymes hemolysis hemolytic
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... • R value = (ALT ... #Enzymes #LFTs ... Transaminitis #diagnosis #differential ... #hepatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... #Diagnosis #hematology
Liver Mass Differential Diagnosis Solid: • Benign: Hepatic Hemangioma, Focal nodular hyperplasia, Hepatocellular adenoma, Regenerative nodules •
Liver Mass Differential ... • Malignant: HCC ... disease, Biliary ... #Mass #Differential ... #Diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... ALP #Elevation #Differential ... Diagnosis #Algorithm #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... , PSC, Alcoholic ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Syndrome, Celiac Disease ... , 1° PSC, Cystic ... #Injury #Differential ... Acute #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... Bile Ducts • PSC ... • Others #LFTs
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypothyroid • Liver ... Disease • Alcohol ... Macrocytic #Anemia #differential ... diagnosis #algorithm #hematology
Liver Mass - Differential Diagnosis Algorithm Cystic: • Benign - Simple: Simple
Liver Mass - Differential ... Disease, Caroli's ... - primary - HCC ... #Mass #Differential ... Algorithm #Causes #Hepatology
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