8 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
(ALP) Elevation ... - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... #Elevation #Differential
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... Transaminase >> Alkaline ... ≥ 2x ULN R Value ... #Transaminitis ... #diagnosis #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
elevation > Alk ... • R value = (ALT ... + ULN ALT) / (alkaline ... #Cholestatic #Transaminitis ... #diagnosis #differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... of cholestatic disease ... disease: > 2 ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
compared with alkaline ... disproportionate increase in alkaline ... HELLP, Celiac disease ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Bilirubin - +/- elevation ... Enzyme Elevation ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
cholestasis → Cirrhosis/Liver ... Labs: • Alkaline ... obstruction • ALP ... or higher • Liver ... bile ducts Differential
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
magnitude of enzyme elevation ... ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase ... disease; T2DM, ... #Differential #