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diagnosis hepatology algorithm injury antibodies associations autoantibodies causes chemistry cholangitis diseases elevated enzymes gap globulin hemolysis hepatitis interpretation liverenzymes liverfunctiontests
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Congenital, Others, Cirrhosis ... - CBD stone, Biliary ... Burak @kwburak #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Cholestatic disease ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... • Others #LFTs
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... /Liver failure ... or higher • Liver ... bile ducts Differential ... #Cirrhosis #PBC
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... function may be abnormal ... hepatitis: < 1 • Cirrhosis ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... hepatitis: < 1 • Cirrhosis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Dermatomyositis Anti-LKM (liver ... Anti-gp210 - Primary biliary ... cirrhosis (PBC) ... Endomyseal antibody (EMA ... diagnosis #table #rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... Blood Smear ↑ abnormal ... #Diagnosis #hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... include extrahepatic biliary ... disease; T2DM, ... #LFTs #Abnormal ... #Differential #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Sarcoidosis) • Liver ... disease: Cirrhosis ... chain assay • An abnormal ... Gap #ProteinGap #differential ... #diagnosis #hematology
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