12 results
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypothyroid • Liver ... Disease • Alcohol ... • Drugs Matthew ... #differential # ... #workup
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... , PCH, Evans Syndrome ... , Liver Disease, ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Recreational Drugs ... #Injury #Differential ... #algorithm #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential ... #hepatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Cold AIHA • PCH ... immune-complex hemolytic anemia ... • Acute HTR ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
or higher • Liver ... bile ducts Differential ... , Sarcoidosis, Drug-induced ... cholangitis #diagnosis #workup ... #hepatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Secondary Causes: - Drug ... - Hemolytic anemia ... deficiency • Liver ... - APLS • Acute
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... RBCs, muscle, liver ... - Prosthetic valves ... Injury: • Early acute ... hepatitis • Acute
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... to bolus these values ... presentations and disease ... circulation If drugs ... 30mmHg) - Severe anemia
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... extremities Drug ... • Antihistone: Drug