12 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... Blood Smear ↑ abnormal ... #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... function may be abnormal ... injury #hepatitis #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... Drug-induced AIHA - Abnormal ... Cold AIHA • PCH ... Prosthetic heart valves ... Algorithm #Causes #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Syndrome, Ischemic Liver ... atherosclerotic lesions ... Hyperhomocysteinemia - Heparin-induced ... pathophysiology #hematology ... #differential #
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... malignancies, Hepatic ... diagnosis #workup #hepatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... hemorrhagic skin lesions ... deficiency • Liver ... #Diagnosis #hematology ... #nonpalpable #dermatology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... thrombin inhibitors, heparin ... • Reduced liver ... amyloidosis #Abnormal ... #hematology #coagulation
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... - If both are normal ... replaced by non-hepatic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Causes #diagnosis #differential ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
of Hemostasis - Differential ... PT/ABNORMAL PTT ... Acquired: • Heparin ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology