9 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... #Diagnosis #Causes ... #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Vascular Causes ... • Iatrogenic: DILI ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Alcoholic hepatitis ... Others #LFTs #Hepatology ... #Causes
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Diagnosis Algorithm ... immune-complex hemolytic anemia ... Prosthetic heart valves ... #Causes #Hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Diagnosis: Viral Hepatitis ... #Pregnancy #hepatology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
disease algorithm ... fibrosis score with values ... 4, fibrosis-4; HCC ... #Referral #Management ... #Hepatology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
- Management Algorithm ... exclude other causes ... HCV, DILI, HCC, ... #Management #Algorithm ... #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
HBV, EBV, VZV, hepatitis ... Sarcoidosis) • Liver ... , PBC, PSC, Viral ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential